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Related Experiment Videos

TAGmapper: a web-based tool for mapping SAGE tags.

P Bala1, Robert W Georgantas, D Sudhir

  • 1Institute of Bioinformatics, International Tech Park, Whitefield Road, Bangalore 560 066, India.

Gene
|August 23, 2005
PubMed
Summary
This summary is machine-generated.

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TAGmapper is a new tool for accurately mapping Serial Analysis of Gene Expression (SAGE) tags to genes. It improves upon existing resources, aiding functional genomics research.

Area of Science:

  • Genomics
  • Bioinformatics

Background:

  • Serial Analysis of Gene Expression (SAGE) provides quantitative gene expression data.
  • Accurate mapping of SAGE tags to genes is crucial for data interpretation.
  • Existing resources for SAGE tag mapping have limitations in accuracy and comprehensiveness.

Purpose of the Study:

  • To develop a web-based tool, TAGmapper, for comprehensive and accurate SAGE tag-to-gene mapping.
  • To address the inadequacy of current resources in assigning SAGE tags to their corresponding genes.

Main Methods:

  • Development of the TAGmapper web-based tool.
  • Comparison of TAGmapper's mapping accuracy against established resources (SAGEmap, SAGE Genie).
  • Experimental validation of TAGmapper's gene assignments using DNA microarrays and quantitative PCR.

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Main Results:

  • TAGmapper provides a more comprehensive and accurate mapping of SAGE tags to genes.
  • TAGmapper successfully mapped tags where other resources failed or provided incorrect assignments.
  • Experimental validation confirmed the reliability of gene expression data derived from TAGmapper assignments.

Conclusions:

  • TAGmapper offers a significant improvement for SAGE tag-to-gene mapping.
  • This tool enhances the reliability of gene identification in SAGE experiments.
  • TAGmapper is expected to be valuable for functional genomic studies.