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Synthesis and biological evaluation of polyhydroxycurcuminoids
Somepalli Venkateswarlu1, Marellapudi S Ramachandra, Gottumukkala V Subbaraju
1Laila Impex Research Centre, Unit 1, Phase III, Jawahar Autonagar, Vijayawada, India.
Abstract:
A series of curcumin analogs (1-3, 5a-5t) was synthesized through the condensation of appropriately protected hydroxybenzaldehydes with acetylacetone, followed by deprotection. The antioxidant activity of these analogs was determined by superoxide free radical nitroblue tetrazolium and DPPH free radical scavenging methods and the polyhydroxycurcuminoids (5l-5s) displayed excellent antioxidant activity. These analogs showed cytotoxicity to lymphocytes and promising tumor-reducing activity on Dalton's lymphoma ascites tumor cells.
