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CpG oligodeoxynucleotides increase the susceptibility of normal mice to infection by Candida albicans
Shuichi Ito1, Joao Pedras-Vasconcelos, Dennis M Klinman
1Section of Retroviral Immunology, CBER/FDA, Bethesda, MD 20892, USA.
Abstract:
Synthetic oligodeoxynucleotides containing CpG motifs trigger an innate immune response that typically increases host resistance to infection. Yet CpG treatment reduces the resistance of normal mice to Candida albicans infection. This effect is mediated by CpG-induced interleukin-12, indicating that CpG-dependent cytokine production may have adverse consequences for the host.
Insights
Synthetic oligodeoxynucleotides with CpG motifs usually boost immunity but unexpectedly decreased resistance to Candida albicans infection in mice. This immune response, driven by interleukin-12, highlights potential adverse effects of CpG-induced cytokine production.
Area of Science:
- Immunology
- Microbiology
- Infectious Diseases
Background:
- Synthetic oligodeoxynucleotides (CpG) are known to stimulate innate immunity, enhancing host resistance against pathogens.
- However, the precise impact of CpG stimulation on specific infections and the underlying mechanisms require further elucidation.
Purpose of the Study:
- To investigate the effect of CpG treatment on host resistance to Candida albicans infection.
- To determine the role of CpG-induced cytokines, specifically interleukin-12, in mediating these effects.
Main Methods:
- Mice were treated with synthetic oligodeoxynucleotides containing CpG motifs.
- Host resistance to Candida albicans infection was assessed post-treatment.
- Interleukin-12 levels were measured to understand its involvement.
Main Results:
- CpG treatment significantly reduced the resistance of normal mice to Candida albicans infection.
- The observed reduction in host resistance was found to be mediated by CpG-induced interleukin-12 (IL-12).
Conclusions:
- CpG-induced cytokine production, particularly IL-12, can have detrimental effects on host defense mechanisms.
- These findings suggest that while CpG motifs can enhance immunity, their application requires careful consideration due to potentially adverse outcomes in certain infections.
