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Updated: Aug 16, 2026

An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug
Published on: June 4, 2021
Ultrasound thrombolysis
Stefan Pfaffenberger1, Branka Devcic-Kuhar, Stefan P Kastl
1Department of Internal Medicine II, University of Vienna, Austria.
Insights
Ultrasound thrombolysis shows promise for treating cardiovascular diseases like heart attack and stroke. Clinical trials are needed to confirm its effectiveness and safety in patient care.
Area of Science:
- Cardiology
- Biomedical Engineering
- Medical Technology
Background:
- Cardiovascular diseases are a leading cause of death globally.
- Thrombolysis is crucial for managing acute myocardial infarction and cerebral insults.
- Existing thrombolytic therapies require safer and more effective adjunctive strategies.
Purpose of the Study:
- To review different technical approaches of Ultrasound Thrombolysis.
- To assess the current performance of Ultrasound Thrombolysis in clinical settings.
- To evaluate the feasibility of Ultrasound Thrombolysis for clinical application.
Main Methods:
- Systematic review of original articles on Ultrasound Thrombolysis.
- Chronological ordering of studies.
- Detailed information on experimental design, acoustical parameters, and thrombolysis outcome.
Main Results:
- Ultrasound Thrombolysis has demonstrated promising results in in vitro and animal studies.
- The report provides an overview of various technical approaches and their clinical performances.
- Data on study design, acoustic parameters, and outcomes are presented chronologically.
Conclusions:
- Ultrasound Thrombolysis is a potential adjunctive strategy to enhance thrombolytic therapies.
- Further clinical trials are necessary to validate its efficacy and safety in patient treatment.
- This overview serves as a guide to the current status and future potential of Ultrasound Thrombolysis.
Abstract:
Cardiovascular diseases are a major cause of mortality in the developed world. Efficacy of thrombolysis plays an important role in the management of acute myocardial infarction and cerebral insult both in the acute event and in the long-term outcome of these patients. New adjunctive strategies have been tested, therefore, to make thrombolytic therapies more effective and safer. Ultrasound Thrombolysis is a technique which showed promising results under in vitro conditions and in animal studies. Now clinical trials have to prove if it is also feasible for clinical application. This report gives an overview on different technical approaches and their current performances in the clinical setting. All original articles are chronologically ordered in tables providing detailed information on each study concerning experimental design, acoustical parameters and thrombolysis outcome.
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