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Body water compartments in patients with obstructive jaundice
A Sitges-Serra1, X Carulla, C Piera
1Department of Surgery, Hospital Universitari del Mar, Autonomous University of Barcelona, Spain.
The British Journal of Surgery
|June 1, 1992
Summary
Obstructive jaundice reduces total body water and extracellular water, including interstitial and plasma volumes. This contraction correlates with reduced kidney function in jaundiced patients.
Area of Science:
- Nephrology
- Gastroenterology
- Physiology
Background:
- Obstructive jaundice can lead to renal dysfunction.
- Understanding the body water compartment changes is crucial for elucidating pathogenesis.
Purpose of the Study:
- To investigate the body water compartments in patients with obstructive jaundice.
- To correlate these changes with renal function and weight loss.
Main Methods:
- Multi-isotope dilution technique used to measure body water compartments.
- Comparison between ten jaundiced patients and ten matched controls.
Main Results:
- Jaundiced patients showed reduced total body water (41.8% vs 46.2%) and extracellular water (20.3% vs 24.3%).
- Reductions were observed in interstitial space (16.1% vs 19.5%) and plasma volume (4.2% vs 4.8%).
- Plasma volume correlated with creatinine clearance (r2=0.56) and extracellular volume (r2=0.77).
Conclusions:
- Obstructive jaundice is associated with a contracted extracellular water compartment.
- Reduced interstitial and plasma volumes may contribute to renal and hemodynamic disturbances in obstructive jaundice.