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[High-sensitive C-reactive protein and Type 2 diabetic nephropathy]
Lan Liao1, Min-xiang Lei, Hui-ling Chen
1Department of Endocrinology, Xiangya Hospital, Central South University, Changshar 410008, China. lanliao_6@hotmail.com
Summary
High-sensitive C-reactive protein (hs-CRP) is elevated in Type 2 diabetic nephropathy (DN). Higher hs-CRP levels may predict DN development in Type 2 diabetes patients.
Area of Science:
- Biochemistry
- Nephrology
- Endocrinology
Context:
- Type 2 diabetic nephropathy (DN) is a major complication of diabetes.
- Early detection and risk stratification for DN are crucial.
- Inflammation plays a role in diabetic complications.
Purpose:
- To investigate the relationship between high-sensitive C-reactive protein (hs-CRP) and Type 2 diabetic nephropathy (DN).
- To assess hs-CRP as a potential predictor of DN development.
- To evaluate changes in hs-CRP with intervention in diabetic patients.
Summary:
- Serum hs-CRP was measured in normal controls, Type 2 diabetic patients without DN, and Type 2 diabetic patients with DN.
- A 5-year prospective study monitored urinary albumin excretion, hs-CRP, and kidney function in diabetic patients without DN.
- Baseline hs-CRP was highest in patients with DN, and higher levels were associated with DN development and persistence.
Impact:
- Elevated hs-CRP may be a risk factor for developing DN in Type 2 diabetes.
- hs-CRP shows potential as a predictive biomarker for DN.
- Understanding inflammation's role can guide therapeutic strategies for diabetic kidney disease.