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Updated: Aug 16, 2026

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
Published on: January 17, 2018
[Expression of pituitary tumor transforming gene, endostatin, and basic fibroblast growth factor mRNAs in invasive
Ling Chen1, Yun-sheng Liu, Lu-shen Wang
1Department of Neurosurgery, Xuanwu Hoaspital, Capital University of Medical Sciences, Beijing 100053. chlyz@sina.com
Objective:
To investigate the effect of the expression of pituitary tumor transforming gene (PTTG), endostatin and basic fibroblast growth factor (bFGF) in invasive pituitary adenomas.
Methods:
Reverse transcription-polymerase chain reaction (RT-PCR) was used to detect the expression of PTTG, endostatin, and bFGF mRNA in invasive and non-invasive pituitary adenomas.
Results:
The expression of PTTG and bFGF significantly increased in the invasive pituitary adenomas (all P < 0.01) compared with those in the non-invasive pituitary adenomas. However, the expression of endostatin significantly decreased in the invasive pituitary adenomas compared with the non-invasive pituitary adenomas (P < 0.01).
Conclusion:
Increased expression of human PTTG and bFGF, and decreased expression of endostatin may be related to the genesis of tumor invasiveness. The feasible mechanism may be related to that the increased expression of PTTG plays a role in pituitary tumor invasiveness by altering the balance of tumor angiogenesis.
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