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Meconium ileus: a review 1972-1990
J G Docherty1, A Zaki, J A Coutts
1University Department of Paediatric Surgery, Royal Hospital for Sick Children, Glasgow, UK.
The British Journal of Surgery
|June 1, 1992
Summary
This study reviewed 53 neonates with meconium ileus and cystic fibrosis. Gastrografin enemas were effective for simple meconium ileus, with good survival rates for both simple and complicated cases.
Area of Science:
- Pediatric Surgery
- Neonatal Care
- Gastroenterology
Background:
- Meconium ileus is a significant complication of cystic fibrosis in neonates.
- Effective management strategies are crucial for improving outcomes.
Purpose of the Study:
- To review the management and mortality of neonates with meconium ileus and cystic fibrosis.
- To evaluate the efficacy and safety of Gastrografin enemas for simple meconium ileus.
Main Methods:
- Retrospective review of 53 neonates treated between 1972 and 1990.
- Analysis of treatment outcomes, including enema success rates and complications.
- Assessment of survival rates for simple and complicated meconium ileus.
Main Results:
- 83% of patients presented with simple meconium ileus.
- Gastrografin enemas successfully treated 26 out of 40 patients with simple meconium ileus.
- The perforation rate from enemas was 5% (4 patients).
- 1-year survival rates were 81% for simple and 75% for complicated meconium ileus.
Conclusions:
- Gastrografin enema is an effective treatment for simple meconium ileus in neonates with cystic fibrosis.
- While complications like perforation can occur, the overall survival rates are encouraging.
- Management of meconium ileus in cystic fibrosis requires careful consideration of treatment options and potential risks.