Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

G2D: a tool for mining genes associated with disease.

Carolina Perez-Iratxeta1, Matthias Wjst, Peer Bork

  • 1Ontario Genomics Innovation Centre, Ottawa Health Research Institute, ON K1H 8L6, Ottawa, Canada. cperez-iratxeta@ohri.ca

BMC Genetics
|August 24, 2005
PubMed
Summary

Researchers developed the Genes to Diseases (G2D) web application to identify candidate genes linked to inherited human diseases. This tool aids in pinpointing genes within specific genomic regions associated with genetic disorders.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

INSPECT-SR: a tool for assessing trustworthiness of randomised controlled trials.

medRxiv : the preprint server for health sciences·2025
Same author

Exploring Detection Methods for Synthetic Medical Datasets Created With a Large Language Model.

JAMA ophthalmology·2025
Same author

Neonatal Vitamin D and Associations with Longitudinal Changes of Eczema up to 25 Years of Age.

Nutrients·2024
Same author

Prenatal vitamin D supplementation mitigates inflammation-related alveolar remodeling in neonatal mice.

American journal of physiology. Lung cellular and molecular physiology·2023
Same author

High variability of COVID-19 case fatality rate in Germany.

BMC public health·2023
Same author

Exome variants associated with asthma and allergy.

Scientific reports·2022

Area of Science:

  • Genomics
  • Medical Genetics
  • Bioinformatics

Background:

  • Human inherited diseases are often genetically linked to specific genomic regions.
  • The complete human genome sequence facilitates the identification of disease-associated genes within these regions.
  • A previously developed algorithm prioritizes candidate genes based on data mining and sequence analysis.

Purpose of the Study:

  • To implement a computational method for identifying candidate genes associated with inherited diseases.
  • To provide a user-friendly web application for exploring genomic regions and their potential disease-related genes.

Main Methods:

  • Development of a web application named G2D (Genes to Diseases).
  • Integration of a gene prioritization algorithm using data mining and gene sequence analysis.

Related Experiment Videos

  • Pre-computation of candidate genes for numerous monogenic diseases and asthma loci.

    • Main Results:

    • The G2D web application is now available for public access.
    • Users can analyze specific human genome regions to identify candidate genes for genetic diseases.
    • Pre-computed analyses cover 552 monogenic diseases lacking identified genes and 18 asthma loci.

    Conclusions:

    • The G2D tool offers a valuable resource for researchers investigating the genetic basis of inherited diseases.
    • Facilitates the discovery of novel gene-disease associations.
    • Accessible online at http://www.ogic.ca/projects/g2d_2/.