Triaryl bis-sulfones as cannabinoid-2 receptor ligands: SAR studies
Bandarpalle B Shankar1, Brian J Lavey, Guowei Zhou
1Department of Chemistry, Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033-0539, USA. bandarpalle.shankar@spcorp.com
Bioorganic & Medicinal Chemistry Letters
|August 24, 2005
Abstract:
We recently reported that compound 1 is a potent inhibitor of the CB2 receptor with high selectivity over CB1. This paper describes the SAR development for this class of compounds. Variation of the substitution pattern on the aromatic rings, as well as the groups linking them together, led to sub-nanomolar inhibitors of the CB2 receptor, with high selectivity over CB1.
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