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[UV-induced skin cancers].
Herbert Hönigsmann1, Thomas L Diepgen
1Klinische Abteilung für Spezielle Dermatologie/Umweltdermatosen, Allgemeines Krankenhaus der Stadt Wien, Medizinische Universität Wien, Osterreich. herbert.hoenigsmann@meduniwien.ac.at
Summary
This review examines UV-induced skin cancers, including basal cell carcinoma, squamous cell carcinoma, and melanoma. While squamous cell carcinoma development is understood, basal cell carcinoma and melanoma require further research due to limited animal models.
Area of Science:
- Dermatology
- Oncology
- Environmental Health
Background:
- Ultraviolet (UV) radiation is a known carcinogen.
- UV-induced skin tumors include basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanoma.
- Epidemiological data strongly link sun exposure to skin cancer development.
Purpose of the Study:
- To review the epidemiology and pathogenesis of UV-induced skin tumors.
- To highlight knowledge gaps in the understanding of BCC and melanoma development.
- To discuss the limitations of current animal models for skin cancer research.
Main Methods:
- Literature review of epidemiological and experimental studies.
- Analysis of current understanding of UV carcinogenesis.
- Comparison of knowledge regarding BCC, SCC, and melanoma.
Main Results:
- Substantial conclusions can be drawn regarding SCC development from experimental data.
- The pathogenesis of BCC and melanoma remains less clear.
- Inadequate animal models hinder a complete understanding of BCC and melanoma biology.
Conclusions:
- Sun exposure is causally linked to skin cancers, primarily based on epidemiological evidence.
- Further research is needed to elucidate the specific pathogenic mechanisms of BCC and melanoma.
- Development of better animal models is crucial for advancing research on these skin malignancies.