Related Experiment Videos
[Bactericidal effects of macrophages of mice treated with interferon]
Comptes Rendus Des Seances De La Societe De Biologie Et De Ses Filiales
|January 1, 1979
Abstract:
The preparations of interferon or virus-inhibiting factor produced in L cell (L-IF) and mouse brain (MB-IF) enhanced the killing of Staphylococcus aureus (S.a.) by the mouse peritoneal macrophage. The L-IF, heat-inactivated at 80 degrees or 60 degrees for 30 min., and mock L-IF could not enhance the killing of S.a. The heterologous human and rabbit interferon preparations didn't enhance the bactericidal activity of macrophage. The L-IF didn't have any effect on the release of lysozyme from the macrophages.
Insights
Interferon preparations from mouse cells significantly boosted macrophage ability to kill Staphylococcus aureus. Heat inactivation or non-specific preparations did not enhance this antibacterial activity.
Area of Science:
- Immunology
- Microbiology
- Cell Biology