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Related Experiment Videos

Rosuvastatin-acenocoumarol interaction.

Sergio Mondillo1, Piercarlo Ballo, Maurizio Galderisi

  • 1Division of Cardiology, University of Siena, Italy. mondillo@unisi.it

Clinical Therapeutics
|August 25, 2005
PubMed
Summary
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A possible interaction between rosuvastatin and acenocoumarol was observed. Rosuvastatin may increase the anticoagulant effect of acenocoumarol, necessitating caution when co-prescribing these medications.

Area of Science:

  • Pharmacology
  • Drug Interactions
  • Cardiovascular Medicine

Background:

  • Hydroxymethylglutaryl coenzyme A-reductase inhibitors (statins) may potentiate oral anticoagulants.
  • Limited prior reports on rosuvastatin and acenocoumarol interaction.

Observation:

  • A 36-year-old male on long-term acenocoumarol experienced increased INR and leg hematoma after starting rosuvastatin.
  • INR levels rose approximately 45 days post-rosuvastatin initiation.

Findings:

  • Discontinuation of both rosuvastatin and acenocoumarol led to a rapid INR decrease.
  • Suggests rosuvastatin enhances acenocoumarol's anticoagulant effect.

Implications:

  • Consider a potential rosuvastatin-acenocoumarol interaction.

Related Experiment Videos

  • Rosuvastatin may increase acenocoumarol's anticoagulant effect.
  • Caution advised when co-administering rosuvastatin with acenocoumarol, especially during discontinuation.