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[IFN-gamma in tear fluid in patients with cystic fibrosis]
Małgorzata Mrugacz1, Beata Zelazowska, Alina Bakunowicz-Lazarczyk
1Z Kliniki Okulistyki Dzieciecej Akademii Medycznej w Białymstoku.
Purpose:
To evaluate IFN-gamma concentration in tear fluid in CF patients.
Material And Methods:
Tear samples were collected from 15 CF patients at the age 10-21, and from 15 patients in control group at the age 11-20. Cytokine levels were determined by ELISA.
Results:
The concentration of IFN-gamma in tear fluid in CF patients was 10.75+/-2.23 pg/ml, and 4.06+/-0.57 pg/ml in control group.
Conclusions:
The results of this study indicate that increased concentration of IFN-gamma in the tear fluid may be an important factor in the pathogenesis of dry eye in CF patients. They also open new perspectives related to therapeutic management.
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