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Meiotic delay of mouse spermatocytes carrying x-ray-induced translocations
P P van Buul1, C M Seelen, J H Goudzwaard
1MGC Department of Radiation Genetics and Chemical Mutagenesis, State University of Leiden, The Netherlands.
Cytogenetics and Cell Genetics
|January 1, 1992
Abstract:
The kinetics of spermatocyte progression through meiotic prophase in cells with or without induced translocations were studied in mice that had been exposed to x-rays. Pulse-labeling experiments using 3H-thymidine, followed by autoradiographic analysis, indicated that at higher x-ray doses (6 and 7 Gy), translocation-carrying cells tend to spend more time in meiotic prophase than do normal cells. At 2 Gy, no such delay seemed to be present. The observed delay may explain the reduction in transmission of translocations to the next generation reported by others.