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From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
Published on: January 13, 2017
Prorocentin, a new polyketide from the marine dinoflagellate Prorocentrum lima
Chung-Kuang Lu1, Hong-Nong Chou, Ching-Kuo Lee
1National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan. cklu@nmmba.gov.tw
Abstract:
Prorocentin (1), isolated from an okadaic acid-producing organism, Prorocentrum lima, possessed all-trans trienes, an epoxide, as well as the 6/6/6-trans-fused/spiro-linked polyether ring moieties. The unique structure supports the proposed cyclization mechanism, polyene formation, epoxidation, and cyclization, of marine polyether toxins. The relative stereostructure was determined on the basis of spectral data. [structure: see text]
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