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Updated: Aug 16, 2026

Improving IV Insulin Administration in a Community Hospital
Published on: June 11, 2012
Force requirements and insulin delivery profiles of four injection devices
Kenichi Toraishi1, Yoichi Yuizono, Noriko Nakamura
1Department of Pharmacy, Saiseikai Fukuoka General Hospital, 1-3-46 Tenjin, Cho-ku, Fukuoka Prefecture, 810-0001 Fukuoka, Japan. toraishi@saiseikai-hp.chuo.fukuoka.jp
Background:
Injection force requirements for four insulin pen-type injection devices were evaluated using the AGS-IkNG Autograph force measurement device (Shimadzu Corp., Kyoto, Japan).
Results:
Compared with the Humulin Pen (the Japanese brand name is Humacart kit; the same device as the Humalog Pen; Eli Lilly, Indianapolis, IN), HumaPen Ergo (Eli Lilly), and NovoPen 3 (Novo Nordisk A/S, Bagsvaerd, Denmark), the InnoLet(Novo Nordisk) required the lowest injection force to both initiate piston movement and commence insulin delivery and required the lowest overall force throughout delivery. InnoLet and NovoPen 3 showed the most even load-displacement curves, suggesting a smoother delivery of insulin during injection. In contrast, the Humulin Pen and HumaPen Ergo demonstrated marked fluctuations in the force required to complete injection.
Conclusions:
These performance characteristics appeared consistent with mechanical features of these insulin delivery devices, and the results highlight the potential importance of careful pen selection for patients with neuromuscular weakness or impaired manual coordination.
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