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Related Experiment Videos

Therapeutic tolerance--does it exist?

Sir Roy Y Calne

    Expert Opinion on Biological Therapy
    |August 27, 2005
    PubMed
    Summary

    Therapeutic tolerance is currently used in clinics, either intentionally or accidentally. This work explores methods to broaden its application and introduces the concept of near tolerance for future research.

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    Area of Science:

    • Immunology
    • Pharmacology
    • Clinical Medicine

    Background:

    • Therapeutic tolerance is an established clinical phenomenon, observed both through intentional interventions and as an incidental outcome.
    • Current clinical applications of therapeutic tolerance are diverse, ranging from autoimmune disease management to transplantation protocols.

    Discussion:

    • This discussion explores strategies to expand the therapeutic window and efficacy of tolerance induction.
    • Investigating the mechanisms underlying both established and emerging forms of tolerance is crucial.

    Key Insights:

    • The concept of 'near tolerance' or 'prope tolerance' is introduced as a potential intermediate state with therapeutic relevance.
    • Understanding the nuances between complete and near tolerance can guide treatment optimization.

    Outlook:

    • Future research should focus on refining methods for predictable tolerance induction.
    • Exploring novel therapeutic targets and personalized approaches to tolerance will be key.
    • Translating these concepts into broader clinical practice holds significant promise.

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