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Potential for drug interactions involving cytochrome P450 in patients attending palliative day care centres: a
A Wilcock1, J Thomas, J Frisby
1Hayward House Macmillan Specialist Palliative Cancer Care Unit, Nottingham City Hospital, Nottingham, UK. andrew.wilcock@nottingham.ac.uk
Aim:
To determine the potential for drug interactions involving cytochrome P450 (CYP) in patients receiving palliative day care.
Methods:
Drugs used by patients attending four specialist palliative day care centres were reviewed to identify combinations that could result in a pharmacokinetic interaction via any of the five main human forms of CYP.
Results:
Of 160 patients, 145 (91%) were prescribed at least one drug that was a substrate, inhibitor or inducer of one of the five main CYP isoforms. Twenty-four drug combinations, involving 34 patients, could have given rise to a clinically important interaction.
Conclusions:
Prescribers should be aware that in this group of patients, one in five are at risk of a clinically important CYP-mediated drug interaction.
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