Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Clinical trial design--towards better practices.

O Correia1, J Faergemann, R Nowicki

  • 1Centro Dermatologia Epidermis, Porto, Portugal.

Journal of the European Academy of Dermatology and Venereology : JEADV
|August 27, 2005
PubMed
Summary

Standardizing clinical trial methods for onychomycosis (fungal nail infection) is crucial for reliable results. Key criteria include clear definitions, controlled trials, and adequate follow-up to ensure accurate treatment efficacy.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Black Hole Spectroscopy and Tests of General Relativity with GW250114.

Physical review letters·2026
Same author

GW250114: Testing Hawking's Area Law and the Kerr Nature of Black Holes.

Physical review letters·2025
Same author

Position statement: Recommendations on the diagnosis and treatment of Malassezia folliculitis.

Journal of the European Academy of Dermatology and Venereology : JEADV·2023
Same author

Guidelines for clinical trials of frontal fibrosing alopecia: consensus recommendations from the International FFA Cooperative Group (IFFACG).

The British journal of dermatology·2021
Same author

Skin Cancer and UV Literacy - Outdoor Workers Study.

Actas dermo-sifiliograficas·2020
Same author

Critical synthesis of available data in Malassezia folliculitis and a systematic review of treatments.

Journal of the European Academy of Dermatology and Venereology : JEADV·2020

Area of Science:

  • Dermatology
  • Clinical Research Methodology
  • Mycology

Background:

  • Recent onychomycosis (fungal nail infection) clinical research exhibits significant methodological variations.
  • Inconsistent inclusion criteria, definitions, and study designs hinder the comparison of treatment outcomes.

Purpose of the Study:

  • To review current methodological approaches in onychomycosis clinical research.
  • To establish essential criteria for conducting conclusive and reliable clinical studies on fungal nail infections.

Main Methods:

  • A literature search of Medline for recent onychomycosis treatment articles.
  • Analysis of variations in study designs, diagnostic criteria, and outcome definitions.

Main Results:

Related Experiment Videos

  • Accurate diagnosis and consideration of predisposing factors at trial entry are critical.
  • Clear definitions for mycological, clinical, and total cure are necessary.
  • Recommended study designs include evidence-based, controlled, double-blind trials with minimal patient dropout (<10-15%).
  • Initial explanatory/pilot studies are advised before initiating larger randomized controlled trials.

Conclusions:

  • Clearly defined sample size, inclusion, and exclusion criteria are paramount.
  • Efficacy assessment must incorporate mycological, clinical, and total cure rates.
  • Minimum study durations should be 18 months for toenail and 9 months for fingernail onychomycosis.