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Antibody-based approaches to diagnosis and characterization of oxidative phosphorylation diseases

B J Hanson1, M F Marusich, R A Capaldi

  • 1Institute of Molecular Biology, University of Oregon, Eugene, OR 97403 1229, USA.

Mitochondrion
|August 27, 2005
PubMed

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Electron Transport Chain: Complex I and II01:46

Electron Transport Chain: Complex I and II

The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...