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Updated: Aug 16, 2026

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue
Published on: May 17, 2018
Mitochondrial dysfunction in cancer
Josephine S Modica-Napolitano1, Keshav K Singh
1Department of Biology, Merrimack College, North Andover, MA 01845, USA.
Abstract:
Nearly a century of scientific research has revealed a number of notable differences in the structure and function of mitochondria between normal and cancer cells, including differences in metabolic activity, molecular composition, and mtDNA sequence. This article reviews several of these differences and discusses their clinical implications, especially with regard to the use of mitochondria as biomarkers for early detection of cancer, or as unique cellular targets for novel and selective anti-cancer agents.
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