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Changing patterns and trends in systemic fungal infections
1Department of Bacteriology and Immunology, University of Helsinki, Helsinki, Finland. Malcolm.Richardson@helsinki.fi
The Journal of Antimicrobial Chemotherapy
|August 27, 2005
Summary
Invasive fungal infections are increasing, with rising rates of Candida glabrata and Aspergillus infections. Antifungal chemoprophylaxis is a promising prevention strategy for at-risk populations.
Area of Science:
- Mycology
- Infectious Diseases
- Public Health
Background:
- Invasive mycoses represent a growing global health concern.
- While Candida albicans bloodstream infections may be declining, infections caused by other Candida species, like Candida glabrata, are increasing.
- Invasive mold infections, particularly Aspergillus, are also becoming more common.
Purpose of the Study:
- To review the evolving epidemiology of invasive fungal infections.
- To examine the impact of medical advancements on fungal infection incidence.
- To highlight emerging challenges such as antifungal resistance.
Main Methods:
- Literature review focusing on epidemiological trends.
- Analysis of risk factors and changing medical practices.
- Overview of fungal infections in specific patient groups.
Main Results:
- Increasing incidence of non-albicans Candida and invasive mold infections.
- Shifting patterns in risk factors and patient populations.
- Fungal opportunistic infections remain a major issue in developing countries with AIDS epidemics.
Conclusions:
- Targeted antifungal chemoprophylaxis shows promise for prevention in high-risk groups.
- Further research is needed to identify and protect populations most vulnerable to fungal infections.
- Antifungal resistance is an emerging threat requiring continued surveillance.