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Related Experiment Videos

Erythropoietic adaptations to endurance training.

L M Weight1, D Alexander, T Elliot

  • 1University of Cape Town Leukaemia Centre, South Africa.

European Journal of Applied Physiology and Occupational Physiology
|January 1, 1992
PubMed
Summary

Endurance athletes show a right-shifted oxygen dissociation curve (ODC) after marathons, indicating normal adaptation. This shift aids exercise but doesn

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Area of Science:

  • Exercise Physiology
  • Sports Science
  • Hematology

Background:

  • Sports anemia is linked to erythropoietic adaptations affecting oxygen dissociation curve (ODC) and erythropoietin (EPO) production.
  • Understanding these adaptations is crucial for athlete health and performance.

Purpose of the Study:

  • To investigate the erythropoietic adaptations in endurance athletes, specifically focusing on ODC shifts and EPO levels.
  • To determine if these adaptations contribute to the phenomenon of sports anemia.

Main Methods:

  • Measured ODC half-saturation pressure in male and female distance runners post-marathon.
  • Assessed erythrocyte 2,3-diphosphoglycerate concentrations.
  • Compared serum EPO concentrations between athletes (triathletes, distance runners) and sedentary controls, and post-exercise in marathon runners.

Main Results:

  • A significant right-shift in the ODC was observed in both male and female distance runners after a marathon.
  • Erythrocyte 2,3-diphosphoglycerate levels were unchanged by exercise but higher in females.
  • Serum EPO levels were not significantly different between athletes and controls, nor altered post-exercise in marathon runners.

Conclusions:

  • The observed ODC shift in endurance athletes is a normal physiological adaptation that likely benefits oxygen delivery during exercise.
  • These findings suggest that the hematological status of these athletes is normal, and the ODC shift does not suppress erythropoietic drive.

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