Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Tissue engineering for jawbone].

Yukihiko Kinoshita1

  • 1Institute for Oral Science, Kanagawa Dental College. kinoshit@kdcnet.ac.jp

Nihon Hotetsu Shika Gakkai Zasshi
|August 27, 2005
PubMed
Summary

Jawbone reconstruction using poly (L-lactic acid) (PLLA) mesh and particulate cancellous bone and marrow (PCBM) shows a high success rate. This method regenerates strong bone suitable for dentures and dental implants.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Recent developments of functional scaffolds for craniomaxillofacial bone tissue engineering applications.

TheScientificWorldJournal·2013
Same author

Gelatin powders accelerate the resorption of calcium phosphate cement and improve healing in the alveolar ridge.

Journal of biomaterials applications·2013
Same author

Bone regeneration by polyhedral microcrystals from silkworm virus.

Scientific reports·2012
Same author

Evaluation of guided bone regeneration with poly(lactic acid-co-glycolic acid-co-ε-caprolactone) porous membrane in lateral bone defects of the canine mandible.

The International journal of oral & maxillofacial implants·2012
Same author

Alveolar bone regeneration using poly-(lactic acid-co-glycolic acid-co-ε-caprolactone) porous membrane with collagen sponge containing basic fibroblast growth factor: an experimental study in the dog.

Journal of biomaterials applications·2011
Same author

Enhanced regeneration of critical bone defects using a biodegradable gelatin sponge and beta-tricalcium phosphate with bone morphogenetic protein-2.

Journal of biomaterials applications·2008

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Oral and Maxillofacial Surgery

Context:

  • Jawbone defects from tumors, cysts, or atrophy pose challenges for dental prosthetics.
  • Effective bone regeneration is crucial for supporting dentures and dental implants.
  • Bioabsorbable materials offer potential for guided bone regeneration.

Purpose:

  • To evaluate the efficacy of bioabsorbable poly (L-lactic acid) (PLLA) mesh combined with particulate cancellous bone and marrow (PCBM) for mandibular reconstruction.
  • To assess the bone formation, stability, and resorption rates following this surgical technique.
  • To determine the suitability of regenerated bone for prosthetic rehabilitation.

Summary:

  • Mandibular defects in 62 patients were reconstructed using PLLA mesh trays filled with PCBM harvested from the ilium.
  • Post-surgery evaluations showed excellent or good results in 83.9% of cases at six months.
  • Long-term observations indicated minimal bone resorption (<10%) in 80% of regenerated bone, supporting prosthetic use.

Impact:

  • This PLLA mesh and PCBM technique demonstrates a high success rate for jawbone reconstruction, enabling functional restoration with dentures and implants.
  • The regenerated bone exhibits good stability and low resorption, improving patient outcomes.
  • Future research should focus on enhancing regeneration in compromised patients through bioactive factors or hybrid bone grafts.

Related Experiment Videos