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Related Concept Videos

Restorative Care01:19

Restorative Care

Restorative care is provided once a patient has been discharged from a healthcare facility and requires additional services. The additional services include home care, rehabilitation programs, and extended care. Restorative care centers help the patient regain their previous level of functioning or acquire a new level of functioning due to the incapacitating effects of a disease or a disability. It aims to assist patients in enhancing their quality of life by encouraging independence,...
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
Development of Human Microbiota01:30

Development of Human Microbiota

The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from the skin...

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Related Experiment Video

Updated: May 23, 2026

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
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Published on: July 24, 2013

Deconditioning in the hospitalized elderly.

Angela Gillis1, Brenda MacDonald

  • 1School of Nursing, St. Francis Xavier University, Antigonish, Nova Scotia.

The Canadian Nurse
|August 27, 2005
PubMed
Summary

Deconditioning, a physiological decline from inactivity, causes significant functional loss in elderly patients, especially after hospitalization. A comprehensive strategy involving specialized care, an elder-friendly environment, and exercise can combat these effects.

Area of Science:

  • Gerontology
  • Physiology
  • Rehabilitation Medicine

Background:

  • Deconditioning is a physiological decline resulting from inactivity, bedrest, or sedentary lifestyles.
  • It leads to functional losses in mental status, continence, and daily activities, commonly affecting elderly individuals during hospitalization.
  • Musculoskeletal effects include diminished muscle mass, strength loss (2-5% daily), muscle shortening, joint structure changes, and reduced leg strength, impacting mobility.

Purpose of the Study:

  • To outline a strategy for combating deconditioning in the elderly.
  • To address the functional losses associated with inactivity and hospitalization.
  • To improve the quality of care for elderly clients experiencing deconditioning.

Main Methods:

  • Describing a three-pronged strategy to combat deconditioning.

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  • Proposing a model of care tailored for the elderly population.
  • Advocating for the creation of an "elder-friendly" hospital environment.
  • Implementing a targeted exercise program.
  • Main Results:

    • The proposed strategy aims to mitigate the adverse effects of deconditioning.
    • Focus on specialized care models and environmental modifications can support elderly patients.
    • Exercise programs are crucial for restoring muscle mass, strength, and mobility.

    Conclusions:

    • A multi-faceted approach is necessary to effectively combat deconditioning in the elderly.
    • Integrating specialized care, supportive environments, and exercise can improve functional outcomes.
    • Addressing deconditioning is vital for reducing falls, frailty, and immobility in older adults.