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Updated: Aug 16, 2026

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
Published on: July 25, 2020
Molecular pathology of ovarian cancer
Francesca Sanseverino1, Giuseppina D'Andrilli, Felice Petraglia
1Department of Gynecology and Obstetrics, University of Siena, Nuovo Policlinico Le Scotte, Siena, Italy.
Abstract:
Ovarian cancer is the leading cause of death among women with gynecologic malignancies. Epithelial tumors typically constitute 80-90% of ovarian malignancies and are classified primarily as serous, mucinous, endometrioid or clear cell. Current data indicate that each of these histologic subtypes is associated with distinct morphologic and molecular genetic alterations. We describe such genetic alterations with specific reference to histologic subtypes.
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