Hemodynamic changes due to stent placement in bifurcating intracranial aneurysms

Area of Science:

• Biomedical Engineering
• Fluid Dynamics
• Medical Device Technology

Background:

• Intracranial aneurysms pose significant risks, and endovascular treatments aim to modify hemodynamics.
• Neuroform stents are used to treat complex aneurysms, but their impact on intraaneurysm flow requires detailed investigation.

Purpose of the Study:

• To quantify changes in intraaneurysm flow dynamics and mechanical stresses after Neuroform stent deployment in bifurcating intracranial aneurysm models.
• To assess the efficacy of Neuroform stents in altering hemodynamic parameters within aneurysms.

Main Methods:

• Utilized a digital particle image velocimetry (DPIV) system to measure pulsatile velocity and shear stress fields.
• Employed a flexible silicone model of bifurcating intracranial aneurysms.
• Placed two Neuroform stents in a Y-configuration and conducted measurements post-deployment.

Main Results:

• Observed a reduction in peak velocity and strength of intraaneurysm vortices post-stenting.
• Demonstrated an up to 11% reduction in the velocity of the jet entering the aneurysm sac.
• Noted a significant decrease (over 40%) in residual vorticity and shear stresses at the end of the cardiac cycle.

Conclusions:

• Neuroform stent placement effectively modifies flow dynamics within bifurcating intracranial aneurysms.
• Stenting reduces hemodynamic forces, potentially mitigating aneurysm progression and rupture risk.
• The study highlights the effectiveness of Neuroform stents in managing complex aneurysm hemodynamics.