The platelet function analyzer (PFA-100): an update on its clinical use

The platelet function analyzer, PFA-100, is a relatively new method which has been developed as a quantitative, simple and rapid in vitro tool of assessing primary hemostasis. The aim of this review is to summarize the published studies reporting on the utility of the PFA-100 device as a screening tool for primary hemostasis. Data were identified by searches of the published literature, including PubMed, references from reviews and abstracts from the most important meetings on this topic. The literature data document that the PFA-100 is a useful screening tool for the investigation of von Willebrand's disease and various acquired and congenital intrinsic platelet function disorders. It is also useful for evaluating primary hemostasis before surgical procedures and for monitoring desmopressin therapy in patients with type 1 von Willebrand's disease. Moreover, recent studies have shown its potential for therapeutic monitoring of the effectiveness of anti-platelet medications in cardiovascular disease management. Given its high sensitivity, speed and simplicity of use, we conclude that the PFA-100 could replace the in vivo bleeding time as a screening test for primary hemostasis in routine clinical practice.