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Related Concept Videos

Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

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Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
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Inflammatory Bowel Disease I: Introduction01:26

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Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows...
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Inflammatory Bowel Disease II: Ulcerative Colitis01:20

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Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal...
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Inflammatory Bowel Disease III: Crohn's Disease01:25

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Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
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Related Experiment Video

Updated: May 3, 2026

Injections of Lipopolysaccharide into Mice to Mimic Entrance of Microbial-derived Products After Intestinal Barrier Breach
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Pericrypt eosinophilic enterocolitis and chronic diarrhea.

R E Clouse1, D H Alpers, D M Hockenbery

  • 1Division of Gastroenterology, Washington University School of Medicine, St. Louis, Missouri.

Gastroenterology
|July 1, 1992
PubMed
Summary
This summary is machine-generated.

Chronic diarrhea may be linked to pericrypt eosinophilic enterocolitis, an unusual finding in intestinal biopsies. This condition, often seen with connective tissue disease, may improve with corticosteroid treatment.

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Area of Science:

  • Gastroenterology
  • Pathology
  • Immunology

Background:

  • Chronic diarrhea lacks clear causes in some patients.
  • Eosinophilic infiltration in the gut is associated with various conditions.
  • Connective tissue diseases can manifest with gastrointestinal symptoms.

Purpose of the Study:

  • To investigate an unusual pattern of eosinophilic infiltration in chronic diarrhea patients.
  • To determine if this pattern represents a distinct pathological entity.
  • To assess the association with systemic connective tissue disease and treatment response.

Main Methods:

  • Analysis of mucosal biopsy specimens from 10 patients with unexplained chronic diarrhea.
  • Histological examination focusing on eosinophilic infiltration patterns.
  • Comparison with biopsy specimens from control groups (asymptomatic, IBS, collagenous colitis, lymphocytic colitis).
  • Clinical follow-up and assessment of treatment response to corticosteroids.

Main Results:

  • An unusual deep eosinophilic infiltration around intestinal crypts was identified.
  • This pattern was distinct from other colitis types and IBS.
  • Half of the patients had concurrent systemic connective tissue disease.
  • Five of seven patients treated with corticosteroids showed symptom improvement and histological resolution.

Conclusions:

  • The findings suggest pericrypt eosinophilic enterocolitis as a cause of chronic diarrhea.
  • This condition is often associated with systemic connective tissue disease.
  • Corticosteroid therapy can be effective in managing this disorder.