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Hepatitis C is a predictor of poorer renal survival in diabetic patients

Errol D Crook1, Sreelatha Penumalee, Bharathi Gavini

  • 1Department of Internal Medicine, Division of Nephrology, Wayne State University School of Medicine, Detroit, Michigan. ecrook@usouthal.edu

Diabetes Care
|August 27, 2005
PubMed

Insights

Hepatitis C virus (HCV) significantly worsens kidney survival in diabetic patients with kidney disease. This risk is independent of other factors, particularly in African Americans.

Area of Science:

  • Nephrology
  • Hepatology
  • Epidemiology

Background:

  • Hepatitis C virus (HCV) infection is prevalent in the U.S.
  • HCV can negatively impact kidney function and survival in certain kidney diseases.
  • Diabetic nephropathy is a leading cause of end-stage renal disease (ESRD).

Purpose of the Study:

  • To investigate the effect of HCV on renal survival in patients with diabetes and kidney disease.
  • To determine if HCV is an independent risk factor for ESRD in this population.

Main Methods:

  • Retrospective chart review of diabetic patients in a nephrology clinic (2001-2002).
  • Data collected included demographics, blood pressure, renal function, medications, and HCV status.
  • Cox proportional hazards analysis was used to assess the impact of HCV on renal survival, with ESRD as the endpoint.

Main Results:

  • HCV prevalence was higher in African Americans (8.09%) compared to non-African Americans (3.93%).
  • Among 312 diabetic patients reviewed, 23 had HCV, predominantly African Americans.
  • HCV patients exhibited worse cumulative renal survival and HCV was a significant independent predictor of ESRD (OR 3.49, P=0.015).

Conclusions:

  • Hepatitis C virus is common in African Americans with diabetes and renal disease.
  • HCV is an independent risk factor for poor renal survival in this population.
  • Further prospective studies are needed to validate these findings.
Abstract

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