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Apolipoprotein E polymorphism and stroke subtypes in an Italian cohort
1Department of Neuroscience, University of Turin, Turin, Italy. paolo_cerrato@yahoo.com
Cerebrovascular Diseases (Basel, Switzerland)
|August 27, 2005
Summary
This study found no significant association between apolipoprotein E (ApoE)-epsilon4 and ischemic cerebrovascular diseases (ICVD) in Italians. ApoE allele frequencies did not differ between patients and controls or among ICVD subtypes.
Area of Science:
- Genetics
- Neurology
- Cardiovascular Research
Background:
- Apolipoprotein E (ApoE)-epsilon4 is a debated risk factor for ischemic cerebrovascular diseases (ICVD).
- Previous studies show conflicting results regarding the association between ApoE-epsilon4 and ICVD risk.
Purpose of the Study:
- To investigate ApoE genotype and allele frequencies in Italian ICVD patients versus healthy controls.
- To compare ApoE allele frequencies across different ICVD subtypes.
Main Methods:
- A hospital-based cohort study included 302 Italian ICVD patients and 228 healthy controls.
- Apolipoprotein E (ApoE) genotype and allele frequencies were analyzed.
- Ischemic stroke subtypes were classified using TOAST criteria.
Main Results:
- No significant differences in ApoE genotype or allele frequencies were observed between ICVD cases and controls.
- ApoE-epsilon4 allele frequency was lower in cases (6%) than controls (10.1%), but not significantly.
- ApoE genotype and allele frequencies did not differ among ICVD subtypes.
Conclusions:
- The study found similar ApoE-epsilon4 genotype and allele frequencies in ICVD patients and control subjects.
- No significant association was found between ApoE-epsilon4 and ICVD risk or its subtypes.