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In vitro Organoid Culture of Primary Mouse Colon Tumors
07:33

In vitro Organoid Culture of Primary Mouse Colon Tumors

Published on: May 17, 2013

Expression of an elongation factor 1 gamma-related sequence in adenocarcinomas of the colon

K Chi1, D V Jones, M L Frazier

  • 1Department of Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston.

Gastroenterology
|July 1, 1992
PubMed

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Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...