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Corticosterone modulates auditory gating in mouse.

Christina R Maxwell1, Richard S Ehrlichman, Yuling Liang

  • 1Division of Neuropsychiatry, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA.

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
|August 27, 2005
PubMed
Summary
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Glucocorticoids impact auditory processing. Low doses of corticosterone enhanced auditory evoked potentials, while high doses impaired them, suggesting a dose-dependent effect on sensory information processing.

Area of Science:

  • Neuroscience
  • Endocrinology
  • Auditory Neuroscience

Background:

  • Circulating glucocorticoids are known to influence sensory processing.
  • Understanding the dose-dependent effects of glucocorticoids on auditory evoked responses is crucial for neurological research.

Purpose of the Study:

  • To investigate the effects of chronic corticosterone administration on auditory evoked responses in mice.
  • To determine how different doses of corticosterone impact the generation, gating, and sensitivity of auditory processing.

Main Methods:

  • C57BL/6 mice were treated with varying doses of corticosterone (0, 1, 5, 15, 30 mg/kg/day) for 14 days.
  • Auditory evoked responses were measured to assess amplitude, gating (recovery cycle), and sensitivity (intensity function).
  • Correlations between circulating corticosterone levels and evoked potential amplitudes were analyzed.

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Main Results:

  • Low-dose corticosterone (5 mg/kg/day) enhanced the amplitude and improved the gating of auditory evoked potentials.
  • Higher doses (15 and 30 mg/kg/day) decreased amplitude and impaired gating of evoked potentials.
  • Stimulus intensity function remained unaffected across all tested doses; lower amplitudes correlated with higher corticosterone levels.

Conclusions:

  • Glucocorticoid levels exhibit a dose-dependent influence on auditory information processing.
  • These findings underscore the importance of considering serum glucocorticoid levels in conditions like schizophrenia and depression.
  • Further research is needed to elucidate the precise mechanisms underlying glucocorticoid modulation of sensory processing.