Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Stem cells and brain cancer.

U Galderisi1, M Cipollaro, A Giordano

  • 1Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, PA, USA. umberto.galderisi@unina2.it

Cell Death and Differentiation
|August 27, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Study of viral integration of HPV-16 in young patients with LSIL.

Journal of clinical pathology·2003
Same author

Interference of bovine herpesvirus 1 (BHV-1) in sorbitol-Induced apoptosis.

Journal of cellular biochemistry·2003
Same author

EGF-responsive rat neural stem cells: molecular follow-up of neuron and astrocyte differentiation in vitro.

Journal of cellular physiology·2003
Same author

Air pollution and respiratory pathology: lung cancer.

Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace·2003
Same author

Differences between 99mTc-sestamibi and 99mTc-tetrofosmin uptake in thyroid and salivary glands: comparison with 99mTc-pertechnetate in 86 subjects.

Nuclear medicine communications·2003
Same author

Burkitt's lymphoma: new insights into molecular pathogenesis.

Journal of clinical pathology·2003
Same journal

A planar dimer of bovine ATP synthase.

Cell death and differentiation·2026
Same journal

GCN5 and TADA2B constitutively regulate XRCC1 function during DNA repair to maintain cell survival.

Cell death and differentiation·2026
Same journal

MEGF8 controls osteogenic differentiation through post-transcriptional regulation of BMP-SMAD signaling in craniosynostosis.

Cell death and differentiation·2026
Same journal

Macrophage-secreted brain-derived neurotrophic factor promotes tumor growth in triple-negative breast cancer by inducing axonogenesis.

Cell death and differentiation·2026
Same journal

Species-specific regulation of necroptosis by STK38-dependent RIPK1 phosphorylation.

Cell death and differentiation·2026
Same journal

Ssu72 phosphatase orchestrates obesogenic adipogenesis and metabolic homeostasis during nutrient excess.

Cell death and differentiation·2026
See all related articles

Cancer stem cells may drive tumor growth and possess self-renewal capabilities similar to normal stem cells. Research indicates these cancer stem cells are present in various solid tumors, including brain cancers.

Area of Science:

  • Oncology
  • Stem Cell Biology
  • Neuroscience

Background:

  • Emerging research suggests cancers harbor cancer stem cells (CSCs).
  • Cancer cells exhibit indefinite proliferation via deregulated self-renewal, a trait shared with stem cells.
  • This implies CSCs may account for certain tumor cell characteristics.

Purpose of the Study:

  • To review evidence for CSCs in brain cancers.
  • To discuss molecular pathways implicated in CSCs.

Main Methods:

  • Review of existing scientific literature on cancer stem cells.
  • Analysis of studies isolating stem cell-like cells from solid tumors, including brain cancers.
  • Examination of molecular pathways potentially involved in CSCs.

Related Experiment Videos

Main Results:

  • Stem cell-like cancer cells have been isolated from various solid tumors.
  • Evidence indicates brain cancers (glioblastomas, medulloblastomas, astrocytomas) contain multipotent neural stem cell-like cells.
  • Molecular pathways involved in CSC physiopathology are being investigated.

Conclusions:

  • Cancer stem cells are a significant area of cancer research.
  • The presence of CSCs in brain tumors suggests a potential role in their development and progression.
  • Understanding CSC molecular pathways is crucial for future therapeutic strategies.