Related Experiment Video
Updated: Aug 13, 2026
Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
Published on: May 26, 2023
Second eye of patients with unilateral neovascular age-related macular degeneration: Caucasians vs Chinese
S Sivaprasad1, W L Membrey, V Sivagnanavel
1Retinal Research Unit, King's College Hospital, Denmark Hill, London, UK.
Purpose:
To investigate the correlation between morphological features of choroidal neovascularisation (CNV) secondary to age-related macular degeneration (AMD) in the first eye and the severity of age-related maculopathy (ARM) in the fellow eyes in two racial groups: Caucasians and Chinese.
Participants:
A total of 135, fluorescein angiograms of patients with unilateral neovascular AMD and ARM in the fellow eyes were included in the study: 38 Caucasians from King's College Hospital, UK; 45 Caucasians from West Kent Eye Centre, UK; 52 Chinese from Hong Kong Eye Hospital, Hong Kong.
Main Outcome Measures:
CNV subtype in the affected eye and ARM severity in the second eyes.
Results:
Although the proportion of CNV subtypes in the three groups were similar, the Chinese cohort showed significantly less ARM severity compared to the Caucasian cohorts (P < 0.05).
Conclusion:
Although drusen and retinal pigmentary changes may be prognostic indicators of CNV, this study suggest that other factors contribute significantly to the pathogenesis of CNV in AMD.
