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Pediatric surface osteosarcoma: clinical, pathologic, and radiologic features.

Sue C Kaste1, Christine E Fuller, Ashish Saharia

  • 1Department of Radiological Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee 38105-2794, USA. sue.kaste@stjude.org

Pediatric Blood & Cancer
|August 27, 2005
PubMed
Summary
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Pediatric surface osteosarcoma (OS) subtypes have different prognoses. Complete surgical resection is key for treatment, while chemotherapy

Area of Science:

  • Orthopedic Oncology
  • Pediatric Oncology
  • Skeletal Tumors

Background:

  • Surface osteosarcoma (OS) is rare, distinct from intramedullary OS.
  • Surface OS presents with varied radiographic and clinical features.
  • Three histologic subtypes of surface OS exist.

Purpose of the Study:

  • To review clinical, radiographic, and pathologic features of pediatric surface OS.
  • To evaluate treatment outcomes for different surface OS subtypes.
  • To determine factors influencing prognosis in pediatric surface OS.

Main Methods:

  • Retrospective review of 14 pediatric surface OS cases (1970-2003).
  • Analysis of clinical, radiographic, and pathologic data.
  • Evaluation of surgical and chemotherapeutic treatment strategies.

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Main Results:

  • Seven parosteal, five periosteal, and two high-grade surface OS cases identified.
  • Median age at diagnosis was 16.2 years; no initial metastatic disease.
  • Complete resection achieved long-term disease-free survival in most patients; chemotherapy use varied by subtype.

Conclusions:

  • Histologic grade is a key predictor of pediatric surface OS behavior.
  • Complete surgical resection is the primary treatment modality.
  • Chemotherapy is not indicated for parosteal OS; its role in periosteal OS requires further investigation.