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Published on: April 6, 2016
Comparative in vitro investigation of the forces exerted by eye drops and eye spray
F Müller1, M Wagner, R H H Neubert
1Institute of Pharmaceutical Technology and Biopharmacy, Department of Pharmacy, Martin-Luther-University, Halle-Wittenberg, Germany.
Abstract:
Topical administration of ophthalmic drugs is predominantly carried out in the form of eye drops. The application of an eye spray represents a feasible alternative to drop instillation with regard to the clinical efficacy. In this study the forces exerted during the application of eye drops and eye spray to a surface were measured in vitro and compared with each other. Whereas the maximal forces that occurred with a falling drop tended to increase with greater application distance, the forces decreased with spraying. From an application distance of 3 cm the eye spray proved to have a more favorable mechanical force effect than the eye drops. In view of the loss of experimental liquid caused by spray application as well as the diameter of the spray cone, a spray distance of from 4 cm to 5 cm can be deemed to be optimal.
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