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Updated: Aug 16, 2026

A Step Beyond BRET: Fluorescence by Unbound Excitation from Luminescence (FUEL)
Published on: May 23, 2014
Quantitative light-induced fluorescence (QLF)--a literature review
J Kühnisch1, R Heinrich-Weltzien
1Ludwig-Maximilians-University, School of Dentistry, Department of Conservative Dentistry and Periodontology, Munich, Germany. jkuehn@dent.med.uni-muenchen.de
Abstract:
This paper on quantitative light-induced fluorescence (QLF) covers the main developments, physical principles, and current application areas of this noninvasive optical method for caries detection. Until now, QLF has mainly been used to detect and monitor initial carious lesions on smooth surfaces, whereas few studies have tried to assess its performance on occlusal pits and fissures. Since it is technically difficult to image proximal lesions, the use of QLF for detecting proximol lesions does not seem very promising from today's point of view. There can be no doubt that the method's great potential lies in the longitudinal observation of in vitro, in situ and in vivo demineralization and remineralization processes.
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