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[The method development of subcritical water chromatography].
Yisong Su1, Jen-Fon Jen, Weibing Zhang
1Department of Chemistry, National Chung-Hsing University, Taichung 402, China.
Se Pu = Chinese Journal of Chromatography
|August 30, 2005
Summary
Subcritical water chromatography (SubWC) offers a novel separation technique using modified instruments for fast analysis of polar compounds. Its selectivity is tunable by adjusting conditions and mobile phase composition.
Area of Science:
- Analytical Chemistry
- Chromatography
Context:
- Subcritical water chromatography (SubWC) utilizes water at high temperatures and pressures, altering its physical properties like polarity and viscosity.
- This novel separation technique is a recent development in high-performance liquid chromatography (HPLC).
Purpose:
- To review the characteristics, instrument design, mobile phase elution, and stationary phase selection for SubWC.
- To highlight the recent advancements and applications of SubWC in separation science.
Summary:
- SubWC employs modified gas or liquid chromatography instruments with packed or capillary columns.
- Selectivity is adjustable via temperature, pressure, and mobile phase additives (organic modifiers, salts).
- Flame ionization and ultraviolet detectors are compatible, broadening application ranges.
Impact:
- SubWC is currently in research and development, primarily for rapid separation of polar and medium-polar samples.
- This technique expands the possibilities for optimizing chromatographic separations and analytical method development.