Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Trade-offs in detecting evolutionarily constrained sequence by comparative genomics.

Eric A Stone1, Gregory M Cooper, Arend Sidow

  • 1Department of Statistics, Stanford University, Stanford, California 94305, USA.

Annual Review of Genomics and Human Genetics
|August 30, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

How parents and community care professionals use a genetic diagnosis to inform care: expanding the concept of utility.

Journal of community genetics·2026
Same author

Path2Omics Enhances Transcriptomic and Methylation Prediction Accuracy from Tumor Histopathology.

Cancer research·2025
Same author

Protein evolution as a complex system.

Nature chemical biology·2025
Same author

Expectations for papers performing Mendelian randomization analyses.

PLoS genetics·2025
Same author

Path2Omics: Enhanced transcriptomic and methylation prediction accuracy from tumor histopathology.

bioRxiv : the preprint server for biology·2025
Same author

Genome Biology of Rust Fungi.

Annual review of phytopathology·2025
Same journal

Common Principles Underlie Mitochondrial DNA Heteroplasmy Dynamics in the Germline and Soma.

Annual review of genomics and human genetics·2026
Same journal

Human Sex Chromosome Biology in the Genomic Era.

Annual review of genomics and human genetics·2026
Same journal

Beyond TADs and Compartments: Mesoscale Chromatin Folding and Its Dynamics in Transcriptional Regulation.

Annual review of genomics and human genetics·2026
Same journal

Experimental and Computational Approaches to Identify Noncoding Pathogenic Variation in Rare Disease.

Annual review of genomics and human genetics·2026
Same journal

How Studying Rare Disease Leads to Mechanistic Insights and Therapeutic Development: Lessons from Nonmammalian Models.

Annual review of genomics and human genetics·2026
Same journal

Synthetic Regulatory Genomics.

Annual review of genomics and human genetics·2026
See all related articles

Comparative genomics aids human genome study by identifying functional elements. Expanding species diversity enhances discovery but presents statistical challenges in analysis.

Area of Science:

  • Comparative genomics
  • Human genome evolution
  • Functional genomic elements

Background:

  • Whole-genome sequencing is expanding to diverse species beyond traditional models.
  • Comparative genomics is crucial for understanding the human genome and its evolutionary history.
  • Identifying functional genomic elements is key to comprehending biological functions.

Purpose of the Study:

  • To review statistical challenges in distinguishing functional genomic elements from neutral genomic sequences.
  • To assess the impact of increasing species diversity on the ability to resolve functional elements.
  • To examine the trade-offs between specificity, sensitivity, and phylogenetic scope in comparative genomics analyses.

Main Methods:

  • Review of comparative genomics literature focusing on specificity, sensitivity, and phylogenetic scope.

Related Experiment Videos

  • Analysis of recent comparative studies utilizing deep alignments of orthologous sequences.
  • Mathematical modeling to assess the influence of sequence diversity on functional element resolution.

    • Main Results:

    • Comparative genomics offers powerful insights into the human genome and its evolution.
    • Discriminating functional elements requires addressing statistical challenges related to sequence comparisons.
    • Expanding species diversity in comparative analyses impacts the resolution of functional elements.

    Conclusions:

    • Comparative genomics is an integral tool for discovering and annotating functional genomic elements.
    • Understanding the trade-offs in specificity, sensitivity, and phylogenetic scope is essential for effective analysis.
    • Future comparative genomic studies must account for the impact of increased species diversity.