Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Biodegradable and photocrosslinkable polyphosphoester hydrogel.

Qiang Li1, Jun Wang, Shilpa Shahani

  • 1Department of Biomedical Engineering, The Johns Hopkins University, Baltimore, MD 21218, USA.

Biomaterials
|August 30, 2005
PubMed
Summary

A novel biodegradable macromer, poly(6-aminohexyl propylene phosphate)-acrylate (PPE-HA)-ACRL, was developed for tissue engineering. The resulting hydrogels show promising mechanical properties, biocompatibility, and potential for bone regeneration scaffolds.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Matrix Stiffness Induces Endothelial Network Senescence.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Src and β-catenin control a senescence-fibrotic phenotype in uterine fibroid cells.

Scientific reports·2026
Same author

Distinct fibroblast and perivascular senotypes define spatial niches that regulate fibrosis.

bioRxiv : the preprint server for biology·2026
Same author

A Defined 3D Hydrogel Model Recapitulates Key Transcriptomic Features of Lung Adenocarcinoma.

Tissue engineering. Part C, Methods·2026
Same author

Towards Reliable Tracking of Natural Killer Cells Using Commercial Iron Oxide Nanoparticles and Magnetic Particle Imaging.

bioRxiv : the preprint server for biology·2026
Same author

γδ T cell-stromal networks modulate matrix composition and vascularity in foreign body response.

Nature communications·2026

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Polymer Chemistry

Background:

  • Developing injectable and biodegradable scaffolds is crucial for tissue engineering.
  • Photocrosslinkable materials offer precise control over scaffold formation.
  • Existing materials may lack the desired combination of mechanical strength and biodegradability.

Purpose of the Study:

  • Synthesize a new biodegradable, photocrosslinkable macromer, poly(6-aminohexyl propylene phosphate)-acrylate (PPE-HA)-ACRL.
  • Characterize the properties of hydrogels formed from this macromer.
  • Evaluate the cytocompatibility and potential for bone regeneration of these hydrogels.

Main Methods:

  • Conjugation of acrylate groups to poly(6-aminohexyl propylene phosphate) (PPE-HA).

Related Experiment Videos

  • Photocrosslinking of the synthesized macromer (PPE-HA)-ACRL to form hydrogels.
  • Characterization of hydrogel properties: swelling ratio, mechanical strength, and degradation.
  • Cytotoxicity assessment using goat mesenchymal stem cells (GMSCs).
  • In vitro culture of encapsulated GMSCs in osteogenic medium and mineralization assessment.

    • Main Results:

    • Successfully synthesized (PPE-HA)-ACRL with varying acrylate content confirmed by 1H NMR.
    • Photocrosslinked hydrogels exhibited elastic properties, with increased acrylate content leading to lower swelling and higher mechanical strength.
    • Hydrogels showed controlled degradation, losing 4.3%–37.4% mass over 84 days.
    • No significant cytotoxicity was observed for (PPE-HA)-ACRL up to 10 mg/ml.
    • Encapsulated GMSCs maintained viability and showed mineralization in osteogenic medium.

    Conclusions:

    • The synthesized (PPE-HA)-ACRL is a promising biodegradable and photocrosslinkable material.
    • The resulting hydrogels possess tunable mechanical properties and good biocompatibility.
    • These injectable hydrogels show potential as scaffolds for bone tissue engineering applications.