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Lateralized cognitive dysfunction and psychotic symptoms in schizophrenia
Michael P Caligiuri1, Joseph B Hellige, Barbara J Cherry
1University of California, San Diego, San Diego, CA, USA. mcaligiuri@ucsd.edu
Schizophrenia Research
|August 30, 2005
Summary
Lateralized cognitive deficits in schizophrenia are domain-specific, not a single core trait. Positive symptoms link to right hemisphere impairment, while negative symptoms associate with left hemisphere dysfunction.
Area of Science:
- Neuroscience
- Cognitive Psychology
- Psychiatry
Background:
- Schizophrenia research extensively studies hemispheric asymmetries.
- It remains unclear if lateralized cognitive dysfunction is a core trait or domain-specific.
Purpose of the Study:
- To determine if lateralized cognitive deficits are core features in schizophrenia.
- To investigate the relationship between lateralized impairments and psychotic/affective symptoms.
Main Methods:
- Assessed performance across multiple lateralized cognitive domains (attention, fluency, memory, perception, arousal).
- Examined 43 schizophrenia subjects and 66 healthy controls.
- Correlated symptom severity with hemispheric performance.
Main Results:
- Schizophrenia subjects showed abnormal right hemisphere recognition memory and left hemisphere arousal.
- Lateralized disturbances are not a single core deficit.
- Positive symptoms correlated with right hemisphere impairment; negative symptoms with left hemisphere impairment.
Conclusions:
- Lateralized cognitive dysfunction in schizophrenia is domain-specific and involves both hemispheres.
- Hemispheric involvement differs based on symptom type (positive vs. negative).