Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The nuclear membrane proteome: extending the envelope.

Eric C Schirmer1, Larry Gerace

  • 1Wellcome Trust Centre for Cell Biology and Institute of Cell Biology, University of Edinburgh, Edinburgh, EH9 3JR, UK. e.schirmer@ed.ac.uk

Trends in Biochemical Sciences
|August 30, 2005
PubMed
Summary

New research reveals that proteins in the nuclear envelope, especially those linked to disease, vary by tissue. This suggests complex functions and explains tissue-specific disorders.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The nuclear envelope protein TMEM209 is an integral component of the nuclear pore complex and interacts with Nup210.

Journal of cell science·2026
Same author

Tubular Lamin- and Emerin-Lined Nuclear Envelope Invaginations Isolate Chromatin Domains for Gene Expression Regulation.

Sub-cellular biochemistry·2025
Same author

Profibrotic Molecules Are Reduced in CRISPR-Edited Emery-Dreifuss Muscular Dystrophy Fibroblasts.

Cells·2025
Same author

Pairing Lamin B1-DamID and Immuno-3D-FISH to Resolve and Verify Peripheral Genome Organization of Adipogenesis.

Methods in molecular biology (Clifton, N.J.)·2025
Same author

Memory CD4+ T cells sequentially restructure their 3D genome during stepwise activation.

Frontiers in cell and developmental biology·2025
Same author

Enhancers on the edge - how the nuclear envelope controls gene regulatory elements.

Current opinion in genetics & development·2024

Area of Science:

  • Cell Biology
  • Proteomics
  • Genomics

Background:

  • Proteomic and cell biology studies have identified proteins in various subcellular organelles.
  • Recent proteomic analysis has revealed numerous new transmembrane proteins in the nuclear envelope.
  • Transcriptome profiling indicates significant variations in the nuclear-membrane proteome across different tissues.

Purpose of the Study:

  • To investigate the functional complexity of the nuclear envelope.
  • To explore how cell-type-specific differences in nuclear envelope protein composition relate to human disorders.

Main Methods:

  • Proteomic analysis to identify nuclear envelope proteins.
  • Transcriptome profiling to assess tissue-specific variations.
  • Analysis of protein sub-complexes, including those with lamin A.

Related Experiment Videos

Main Results:

  • Identification of many new putative transmembrane proteins in the nuclear envelope.
  • Demonstration of significant tissue-specific variations in the nuclear-membrane proteome.
  • Highlighting the role of cell-type-specific differences in protein sub-complexes, particularly involving lamin A.

Conclusions:

  • The nuclear envelope possesses unexpected functional complexity.
  • Tissue-specific differences in nuclear envelope proteins may explain the etiology of nuclear-envelope-linked human disorders.