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Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Semantic representation of consumer questions and physician answers
Laura A Slaughter1, Dagobert Soergel, Thomas C Rindflesch
1Center for Shared Decision Making and Nursing Research, Rikshospitalet-Radiumhospitalet RH, Forskningsveien 2b, 4. etg., 0027 Oslo, Norway. laura.slaughter@rikshospitalet.no
Abstract:
The aim of this study was to identify the underlying semantics of health consumers' questions and physicians' answers in order to analyze the semantic patterns within these texts. We manually identified semantic relationships within question-answer pairs from Ask-the-Doctor Web sites. Identification of the semantic relationship instances within the texts was based on the relationship classes and structure of the Unified Medical Language System (UMLS) Semantic Network. We calculated the frequency of occurrence of each semantic relationship class, and conceptual graphs were generated, joining concepts together through the semantic relationships identified. We then analyzed whether representations of physician's answers exactly matched the form of the question representations. Lastly, we examined characteristics of the answer conceptual graphs. We identified 97 semantic relationship instances in the questions and 334 instances in the answers. The most frequently identified semantic relationship in both questions and answers was brings_about (causal). We found that the semantic relationship propositions identified in answers that most frequently contain a concept also expressed in the question were: brings_about, isa, co_occurs_with, diagnoses, and treats. Using extracted semantic relationships from real-life questions and answers can produce a valuable analysis of the characteristics of these texts. This can lead to clues for creating semantic-based retrieval techniques that guide users to further information. For example, we determined that both consumers and physicians often express causative relationships and these play a key role in leading to further related concepts.
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