Related Experiment Video
Updated: Aug 16, 2026

Expression of Transgenes in Native Bladder Urothelium Using Adenovirus-Mediated Transduction
Published on: October 6, 2022
A novel hypothalamic neuroendocrine peptide: URP (urotensin-II-related peptide)?
Johann-Günther Egginger1, André Calas
1CNRS UMR 7101, université Pierre-et-Marie-Curie, Paris-6, 7, quai Saint-Bernard, 75252 Paris cedex 05, France. johann.egginger@sny.jussieu.fr
Abstract:
Urotensin-II-related peptide (URP) is an eight-amino-acid peptide recently isolated from rat brain and considered as the endogenous ligand for the urotensin-II receptor. Immunohistochemical treatment of mouse brain sections with anti-URP antibodies revealed numerous immunopositive fibres in the median eminence and vascular organ of the lamina terminalis as well as labelled cell bodies, mainly in the preoptic area. In consecutive serial sections, in situ hybridization demonstrated URP-mRNA in neuronal perikarya. Double-immunofluorescence labelling showed a co-localization of URP and GnRH in fibres and cell bodies. These results suggest the existence of URP as a novel hypothalamic neuroendocrine peptide co-localized and possible co-released with GnRH.
Related Concept Videos
Transducer Mechanism: Enzyme-Linked Receptors
Major types that are helpful drug targets include:
Anatomy of the Genitourinary System II: Bladder and Urethra
Regulation of Food Intake
Hormonal Regulation
Urinary Tract Infection II: Pathophysiology
Ureters
