Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[B lymphocytes--a dogma revisited].

Jacques Couderc1

  • 1Inserm 131, Cytokines et Immunorégulations, 32, rue des Carnets, 92140 Clamart, France. jacques.couderc@inserm.ipsc.u-psud.fr

Comptes Rendus Biologies
|August 30, 2005
PubMed
Summary

The one B cell-one antibody hypothesis is challenged by findings that B cells can produce two different antibodies. This discovery of "double producers" offers new insights into autoimmunity and immunoglobulin repertoire.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Obesity-induced lymphocyte hyperresponsiveness to chemokines: a new mechanism of Fatty liver inflammation in obese mice.

Gastroenterology·2008
Same author

Effects of exogenous IL-2 administration on the homeostasis of CD4+ T lymphocytes.

Journal of clinical immunology·2004
Same author

Role of the chemokine stromal cell-derived factor 1 in autoantibody production and nephritis in murine lupus.

Journal of immunology (Baltimore, Md. : 1950)·2003
Same author

Synthesis of glucocorticoid-induced leucine zipper (GILZ) by macrophages: an anti-inflammatory and immunosuppressive mechanism shared by glucocorticoids and IL-10.

Blood·2002
Same author

Interleukin-10 modulates the sensitivity of peritoneal B lymphocytes to chemokines with opposite effects on stromal cell-derived factor-1 and B-lymphocyte chemoattractant.

Blood·2002

Area of Science:

  • Immunology
  • Molecular Biology

Context:

  • The long-standing 'one B cell, one antibody' hypothesis has been challenged.
  • Recent findings indicate B cells can express multiple B cell receptors (BCRs).
  • This challenges the original concept proposed by M.F. Burnet in 1957.

Purpose:

  • To explore the implications of B cells expressing multiple BCRs.
  • To investigate the role of 'double producers' in autoimmunity.
  • To understand the impact on the immunoglobulin repertoire.

Summary:

  • B cells can simultaneously express auto-reactive BCRs and BCRs against non-self antigens, allowing escape from negative selection.
  • Studies demonstrate normal B cells producing antibodies against two unrelated haptens.
  • 'Double producers' present novel perspectives for understanding and potentially treating autoimmune diseases.

Impact:

  • Challenges fundamental concepts in immunology, specifically B cell receptor expression.
  • Suggests 'double producers' play a significant role in the development and amplification of the immunoglobulin repertoire.
  • Opens new avenues for research into autoimmune diseases and B cell biology.

Related Experiment Videos