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Rationale for T cell inhibition by cyclosporin A in major autoimmune diseases
G F Ferraccioli1, P Tomietto, M De Santis
1Division of Rheumatology, Department of Internal Medicine and Geriatrics, Catholic University of the Sacred Heart, Complesso Integrato Columbus Via Moscati 31, 00168 Rome, Italy. gf.ferraccioli@rm.unicatt.it
Abstract:
T cells exert a fundamental role in different autoimmune chronic inflammatory diseases. The low-affinity autoreactive T cell clones provide the first amplification loop after the antigen (AgX) presentation, and if not counterregulated by the T regulatory cells (Treg), they maintain the inflammation and predispose to organ damage. Interrupting the T cell amplification loop through calcineurin antagonists leads to maintenance of the whole process under the autoimmune threshold.
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