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Published on: August 18, 2016
Hypoadiponectinemia is associated with coronary artery spasm in men
Hidetomo Maruyoshi1, Sunao Kojima, Fumiyuki Otsuka
1Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Summary
Low adiponectin levels (hypoadiponectinemia) are linked to coronary spastic angina (CSA) in men. This finding suggests hypoadiponectinemia may be an independent risk factor for CSA.
Area of Science:
- Cardiology
- Endocrinology
- Vascular Biology
Background:
- Coronary spastic angina (CSA) involves coronary endothelial dysfunction.
- The role of adiponectin in CSA pathogenesis is not well understood.
Purpose of the Study:
- To investigate the relationship between plasma adiponectin levels and CSA in men.
- To determine if adiponectin is an independent risk factor for CSA.
Main Methods:
- Examined plasma adiponectin concentrations in 55 men with CSA and 55 with chest pain syndrome (CPS).
- Utilized multiple logistic regression analysis to identify independent determinants of CSA.
Main Results:
- Plasma log-adiponectin levels were significantly lower in CSA patients compared to CPS patients (p < 0.0001).
- Smoking prevalence was higher in CSA patients (50.9%) than in CPS patients (29.1%) (p = 0.0195).
- Log-adiponectin (p = 0.0008) and smoking (p = 0.0210) were identified as independent determinants of CSA.
Conclusions:
- Hypoadiponectinemia is a potential risk factor for CSA in men.
- This association is independent of smoking status.
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