Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gastrulation01:56

Gastrulation

Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata will form...
Gastric Motility01:16

Gastric Motility

Gastric motility is the coordinated contraction and relaxation of stomach muscles that convert ingested food into chyme, a semi-liquid substance ready for further digestion in the intestines. The process begins with the vagus nerve inducing the relaxation of the smooth muscles in the fundus and body of the stomach, allowing these regions to expand and accommodate up to approximately 1.5 liters of food and liquid.
Peristaltic Waves and Chyme Formation
Upon food entry, the stomach initiates...
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A case of vitamin D-dependent rickets type 2A presenting with hypophosphatemia without hypocalcemia.

JCEM case reports·2026
Same author

Risk of Bias in Experiments, Quasi-Experiments and Natural Experiments Across Disciplines: Discussion Paper and Assessment Framework.

Campbell systematic reviews·2026
Same author

Macrophage Polarization and Spatial Architecture Characterize the Tumor Immune Microenvironment and Prognosis in Hepatoblastoma.

The American journal of pathology·2026
Same author

Genetics of skeletal proportions across two different populations.

American journal of human genetics·2026
Same author

Height-for-age adjusted bone mineral density and associated factors in youth with type 1 diabetes.

Bone·2026
Same author

Therapy-Associated Polyposis in Pediatric Cancer Survivors.

Pediatric blood & cancer·2026

Related Experiment Video

Updated: Jun 16, 2026

Oral Gavage in Neonatal Mouse Pups and Functional Assessment of Gut Barrier Integrity Using Ussing Chambers
07:18

Oral Gavage in Neonatal Mouse Pups and Functional Assessment of Gut Barrier Integrity Using Ussing Chambers

Published on: January 9, 2026

GATA-4:FOG interactions regulate gastric epithelial development in the mouse.

Christina M Jacobsen1, Susanna Mannisto, Susan Porter-Tinge

  • 1Department of Pediatrics, Washington University School of Medicine, St. Louis Children's Hospital, St. Louis, MO 63110, USA.

Developmental Dynamics : an Official Publication of the American Association of Anatomists
|August 30, 2005
PubMed
Summary

Transcription factor GATA-4 and its cofactor FOG-1 are crucial for mouse hindstomach development. Their interaction regulates essential gene expression and epithelial-mesenchymal signaling during stomach organogenesis.

More Related Videos

Enhanced Spatial Mapping of Mouse Gastric Muscle Layers Using a Modified Swiss Roll Technique
04:18

Enhanced Spatial Mapping of Mouse Gastric Muscle Layers Using a Modified Swiss Roll Technique

Published on: November 25, 2025

Mouse Fetal Whole Intestine Culture System for Ex Vivo Manipulation of Signaling Pathways and Three-dimensional Live Imaging of Villus Development
06:46

Mouse Fetal Whole Intestine Culture System for Ex Vivo Manipulation of Signaling Pathways and Three-dimensional Live Imaging of Villus Development

Published on: September 4, 2014

Related Experiment Videos

Last Updated: Jun 16, 2026

Oral Gavage in Neonatal Mouse Pups and Functional Assessment of Gut Barrier Integrity Using Ussing Chambers
07:18

Oral Gavage in Neonatal Mouse Pups and Functional Assessment of Gut Barrier Integrity Using Ussing Chambers

Published on: January 9, 2026

Enhanced Spatial Mapping of Mouse Gastric Muscle Layers Using a Modified Swiss Roll Technique
04:18

Enhanced Spatial Mapping of Mouse Gastric Muscle Layers Using a Modified Swiss Roll Technique

Published on: November 25, 2025

Mouse Fetal Whole Intestine Culture System for Ex Vivo Manipulation of Signaling Pathways and Three-dimensional Live Imaging of Villus Development
06:46

Mouse Fetal Whole Intestine Culture System for Ex Vivo Manipulation of Signaling Pathways and Three-dimensional Live Imaging of Villus Development

Published on: September 4, 2014

Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Genetics

Background:

  • Transcription factor GATA-4 plays a vital role in mouse hindstomach cytodifferentiation.
  • GATA-4 functions by cooperating with Friend-of-GATA (FOG) cofactors to regulate gene expression.

Purpose of the Study:

  • To investigate the role of GATA-4 and FOG cofactors in mouse hindstomach development.
  • To elucidate the mechanism by which GATA-4:FOG interactions influence gene expression and signaling pathways.

Main Methods:

  • Immunohistochemical staining to detect GATA-4 and FOG-1 expression in embryonic mouse hindstomach.
  • Analysis of Gata4(ki/ki) mutant mice, which have impaired GATA-4:FOG binding, to assess developmental consequences.

Main Results:

  • GATA-4 and FOG-1 were co-expressed in hindstomach epithelial cells during critical developmental stages (E11.5-18.5).
  • FOG-2 was not detected in the gastric epithelium.
  • In Gata4(ki/ki) mice, Sonic Hedgehog was over-expressed, and fibroblast growth factor-10 was decreased, indicating disrupted signaling.

Conclusions:

  • Functional interaction between GATA-4 and FOG-1 is essential for proper epithelial-mesenchymal signaling in the developing stomach.
  • This interaction is required for the precise regulation of gene expression critical for hindstomach organogenesis.